求助,为什么二审返修后,有的回复审稿人意见的意见没有改变

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【求助】meta分析论文返修,各位战友看看审稿人的意见
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各位从事meta分析的老师:本人初次尝试写了篇meta分析,论文返修,审稿人提出了以下几个问题,希望各位战友能给点提示,如何回复这几个问题1.我在文中Literature search部分写到:All published and unpublished studies comparing … … versus … … were included if they met the inclusion criteria.” 实际上搜索到文献仅限published studies,并无 unpublished studies.审稿人问:How the unpublished materials were obtained for preventing the “publication bias” should be stated in the manuscript. What strategy did authors use to deal with the “publication bias” should also be explained.2. 审稿人问:In this study, 7 articles were put together for analysis. There is considerable clinical heterogeneity among articles, i.e. clinical differences exist in the studied papers with respect to baseline characteristics of patients, interventions and outcomes. Disease severity of subjects, medication dosage, time of medication varied among the articles. How did the authors deal with this clinical heterogeneity should be addressed in the article.3.我在Methods部分描叙统计方法:For continuous outcome data (e.g., mean surgical time) means and standard deviations were used to calculate a weighted mean difference (WMD)审稿人问:The authors did not describe what kind of weighted mean difference (WMD) they used. More details should be provided by the authors.该如何解释WMD,好像很多meta分析论文中并不对这个做定义解释。
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对于第三条,我刚好看到别人文献上是这么解释的1.for each study included, the outcomes were reported in the same way,the difference between two means was not standardized by dividing within group standard deviation. In this case, the pooled estimate of mean difference is "Weighted Mean Difference"(WMD)2.for each study included, the outcomes were reported in differnce way,the difference between two means was not standardized by dividing an sdtimate of the with-in group standard deviation. In this case, the pooled estimate of mean difference is "Standardized Mean Difference"(SMD)
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对于第三条,我刚好看到别人文献上是这么解释的1.for each study included, the outcomes were reported in the same way,the difference between two means was not standardized by dividing within group standard deviation. In this case, the pooled estimate of mean difference is "Weighted Mean Difference"(WMD)2.for each study included, the outcomes were reported in differnce way,the difference between two means was not standardized by dividing an sdtimate of the with-in group standard deviation. In this case, the pooled estimate of mean difference is "Standardized Mean Difference"(SMD)
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感谢各位战友的关注,这份Response绞尽脑汁地回复给了杂志,尽管并不完美,杂志勉强接受。Accepted!(IF:2.9)下面列出了本人的答复,供各位参考。1.审稿人问:How the unpublished materials were obtained for preventing the “publication bias” should be stated in the manuscript. What strategy did authors use to deal with the “publication bias” should also be explained.Response:
Thanks for your comment. In fact, only published studies were included for this meta-analysis. We have made this clear in the revised manuscript by adding some sentences on study inclusion: “All published studies comparing ...” “Discussion” section briefly added limitations of this meta-analysis: “we cannot fully exclude publication bias …, we did not attempt to gain access to unpublished results.”
“Publication bias analysis” was added to the “statistical analysis” section. The analysis result was added to the “results” section. “Discussion” section also now has briefly touched on this: “we cannot fully exclude publication bias. There were no sufficient studies to detect asymmetry in a funnel plot.”2.审稿人问:In this study, 7 articles were put together for analysis. There is considerable clinical heterogeneity among articles, i.e. clinical differences exist in the studied papers with respect to baseline characteristics of patients, interventions and outcomes. Disease severity of subjects, medication dosage, time of medication varied among the articles. How did the authors deal with this clinical heterogeneity should be addressed in the article.Response:
Thanks for your comment.
Methods, Results and Discussion all section now have designated space on presenting and discussing on we addressed the heterogeneity issue among studies selected in the meta-analysis with study comparison details such as dosing, disease severity and indication divergence.Indeed, we may consider this meta-analysis as a multicenter randomized controlled trial. There were no significant differences in ... baseline of patients (listed in table 1) in each study, and mostly system baseline were also not significant different. These conformed to the principle of meta-analysis. Although the severity of disease and interventions (type of ... and other intraoperative treatment) were different, each study balanced these factors. The comparative outcomes of the treatment and control groups were not biased by these factors, and the aim focused on the different clinical outcome of ... under same conditions. The treatment group and control group were treated under the mostly equal conditions in each study. So the clinical heterogeneity was thought as minimal when performing meta-analysis.
Additionally, the statistical heterogeneity (I2 test) of meta-analysis also reflected the clinical heterogeneity. How to deal with this heterogeneity was briefly addressed in the Statistical analysis part. We used the Q statistic of Chi-square value test and inconsistency index (I-squared, I2) to estimate the heterogeneity of individual studies contributing to the pooled estimate. The homogeneity was to evaluate if the differences across the studies are greater than expected by chance alone.
P < 0.05 suggests presence of heterogeneity beyond what could be expected by chance alone.
I-squared (I2) describes the percentage of total variation across studies due to heterogeneity rather than chance and was also used as a measure to quantify the amount of heterogeneity. I2 > 50% suggests heterogeneity. In “results” section, if heterogeneity was significant, we addressed reasons and cautions to reader. In “discussion” section, we added limitation of this meta-analysis and listed the cause of heterogeneity: “Second, the studies included were heterogeneous in terms of study location, population, number of patients of different studies, basal condition. Access to individual level data could certainly have improved the quality of adjustment as well as the precision of estimates.”3.审稿人问:The authors did not describe what kind of weighted mean difference (WMD) they used. More details should be provided by the authors.Response:
Thanks for your comment.
Two summary statistics are commonly used for meta-analysis of continuous data: the weighted mean difference and the standardized mean difference. WMD can be used as a summary statistic in meta-analysis when outcome measurements in included trials are made on the same scale (e.g., surgical time in the present study). SMD is used as a summary statistic in meta-analysis when the trials all assess the same outcome, but measure it in a variety of ways (for example, all trials measure depression but they use different psychometric scales).
In this meta-analysis, we used WMD according to the methods recommended in the Cochrane Handbook for Systematic Reviews of Interventions. The definition of WMD is determined by principle and method of meta-analysis. I am sorry for not describing clearly WMD. Because of limiting of word, this meta-analysis briefly addressed it in “statistical analysis” section.
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求助,为什么二审返修后,审稿人的意见没有改变啊已有1人参与
哪位虫友遇到过这种情况,二次审核意见返回来了,状态直接变成第3轮审核,可是编辑给的信里面,让提交修改稿,可是我发现第一个审稿人A的意见和第一次审稿人D的6个主要审稿意见还是一样的;第二个审稿人B的意见和第一次里面的审稿人E的意见有一个一模一样,其余两个变了。这是怎么回事啊。是审稿人对意见都不满意吗?还是怎么回事啊?有谁遇到过吗?我第一次也是把修改说明里一条一条都回答了。现在想写封信询问下编辑,是否有什么错误。但是不知道该怎么写比较好,请各位虫友帮忙,给个模板之类的!非常感谢!
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【答案】应助回帖
感谢参与,应助指数 +1
是不是某个比较重要的点你没改过来
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引用回帖:: Originally posted by 默默大大 at
是不是某个比较重要的点你没改过来 可六个意见还是完全一样,难道是都不满意?
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