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网易公司版权所有(C)杭州乐读科技有限公司运营：B6.Cg-Tg(Vil1-cre)997Gum/J
Villin-cre
Also Known As: Villin-cre , 12.4KbVilCre line 997
These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis. In contrast to Villin-cre transgenic mice from founder line 1000 (Stock No. ) that are reported be absent of Cre recombinase activity in gonads, these Villin-cre transgenic mice from founder line 997 are reported to have a very low level (&1%) of cells with Cre recombinase activity in the testes.
Donating Investigator Deborah L Gumucio, University of Michigan
Genetic overview
Genetic Background
Generation
Allele Type
Transgenic
(Recombinase-expressing)
Research Applications
Cancer ResearchResearch Tools
Base Price
Starting at:
$255.00 Domestic price for female
$329.00 Domestic price for breeder pair
Detailed Description
Villin-cre transgenic mice have the mouse villin 1 promoter directing expression of Cre recombinase to villus and crypt epithelial cells of the small and large intestines, in a pattern that closely resembles endogenous Vil1 expression. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. The donating investigator indicates that expression is generally continuous, but that a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil1 gene expression onset of 9.0 dpc. Villin-cre transgenic mice from founder line 997 (Stock No. 004586) are reported to have a very low level (&1%) of cells with Cre recombinase activity in the testes. This is in contrast to Villin-cre transgenic mice from founder line 1000 (Stock No. ) that are reported be absent of Cre recombinase activity in gonads.Villin-cre transgenic mice from founder line 997 (also called Vil1-Cre 997, Vil-Cre 997, Villin-Cre 997, 12.4KbVilCre 997 or VCre997) are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities as hemizygotes. The phenotype of homozygous Vil1-Cre 997 mice is not reported.
Development
The 12.4KbVilCre transgene was designed by Dr. Blair Madison (University of Michigan) to have the 12.4 kb fragment of the mouse villin 1 gene, the Cre recombinase coding domain and a metallothionein polyadenylation site sequence. This transgene was injected into the pronuclei of fertilized C57BL/6J x SJL/J mouse eggs. Several founder animals were bred to C57BL/6 mice for germline transmission, and founder line 997 (also called Vil1-Cre 997, Vil-Cre 997, Villin-Cre 997, 12.4KbVilCre 997 or VCre997) was established. The donating investigator reports that Vil1-Cre 997 mice were subsequently backcrossed to C57BL/6 mice for five generations. Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J (Stock No. ) at least once to establish the colony.
Expression Data
Expressed Gene
cre, cre recombinase, bacteriophage P1Site of Expressionepithelial cells of the small
onset of expression is at 12.5 d.p.c.; expression is generally continuous, but a small amount of mosaicism is noted in the colon
Control Suggestions
Noncarrier
Additional Information
Selected ReferencesMadison BB; Dunbar L; Qiao XT; Braunstein K; Braunstein E; Gumucio DL. 2002. cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine. J Biol Chem 277(36):33275-83.
Tg(Vil1-cre)997Gum
Allele Symbol:
Allele Name
transgene insertion 997, Deborah L Gumucio
Allele Type
Transgenic (Recombinase-expressing)
Allele Synonym(s)
12.4KbVilC Tg(Vil-cre)997Gum; Vcre; Vil-C VilC Villin- Villin. VillinCre
Gene Symbol and Name
, transgene insertion 997, Deborah L Gumucio
Gene Synonym(s)
12.4KbVilC Tg(Vil-cre)997G Tg(Vil-cre)997G Tg(Vil-cre)997Gum; Villin- Villin. VillinCre
PromoterVil1, villin 1, mouse, laboratoryExpressed Genecre, cre recombinase, bacteriophage P1Site of Expressionepithelial cells of the small
onset of expression is at 12.5 d.p.c.; expression is generally continuous, but a small amount of mosaicism is noted in the colon
Strain of Origin
(C57BL/6J x SJL)F1
Chromosome
General Note
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Molecular Note
A 12.4-kb promoter fragment from the villin 1 gene drives the expression of cre recombinase. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. Line 997 contains 16 copies of the transgene inserted in chromosome 17 about 119 kb upstream of
(chr17:55,466,255; NCBI37/mm9) with a 14.6 kb deletion at the integration site.
Mutations Made By
Blair Madison, University of Michigan
Disease Terms
This mouse can be used to support research in many areas including:
Cancer ResearchCre-lox SystemCre recombinase expressionResearch ToolsCancer ResearchCre-lox SystemCre-lox SystemCre Recombinase ExpressionDevelopmental Biology ResearchCre-lox SystemGenetics ResearchMutagenesis and TransgenesisMutagenesis and Transgenesis: Cre-lox SystemTissue/Cell Markers: Cre-lox SystemTissue/Cell Markers: endothelial cellsGenotype: cre relatedResearch ToolsCre-lox SystemGenetics ResearchMutagenesis and TransgenesisMutagenesis and Transgenesis: Cre-lox System
References
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