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Histone H2A-Bbd type 2/3H2AFB2 Homo sapiens (Human)-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveliFunctioniAtypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.Manual assertion based on experiment ini"Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA.", , , , , , , ,
[] [] []Cited for: FUNCTION, DOMAIN."Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.", , , ,
[] [] []Cited for: FUNCTION."Dissection of the unusual structural and functional properties of the variant H2A.Bbd nucleosome.", , , , , , , , , , ,
[] [] []Cited for: FUNCTION."ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes.", , , , , ,
[] [] []Cited for: FUNCTION."H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way.", ,
[] [] []Cited for: FUNCTION."Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd.", , ,
[] [] []Cited for: FUNCTION."Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION.MiscellaneousIn contrast to other H2A histones, it does not contain the conserved residues that are the target of post-translational modifications.GO - Molecular functioniGO - Biological processiInferred from mutant phenotypeiInferred from direct assayiKeywordsiMolecular functionBiological processNames & TaxonomyiProtein namesiRecommended name:Histone H2A-Bbd type 2/3Alternative name(s):H2A Barr body-deficientShort name: H2A.BbdGene namesiName:ANDName:Synonyms:H2ABBD, H2AFBOrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome X Organism-specific databasesEuPathDBi
HGNCi H2AFB2.
H2AFB3. MIMi gene. neXtProti Subcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoskeleton
Peroxisome
Golgi apparatus
Mitochondrion
Manual annotation
Automatic computational assertionGraphics by Christian S Source: "H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.", , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.Other locations Manual assertion based on experiment ini"H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.", , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY."Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells.", , , , ,
[] [] []Cited for: FUNCTION, SUBCELLULAR LOCATION.Note: Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.Manual assertion based on experiment ini"H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.", , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.Keywords - Cellular componenti, , Pathology & BiotechiOrganism-specific databasesPharmGKBi Polymorphism and mutation databasesDMDMi PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_Histone H2A-Bbd type 2/3 115Proteomic databasesPaxDbi PeptideAtlasi PRIDEi PTM databasesiPTMneti PhosphoSitePlusi ExpressioniTissue specificityiPresent in mature sperm.Manual assertion based on experiment ini"H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.", , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.Gene expression databasesBgeei CleanExi
Genevisiblei HS. InteractioniSubunit structureiThe nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. May be incorporated into a proportion of nucleosomes, replacing one or more H2A molecules.Binary interactionsiWithEntry#Exp.IntActNotesHIST1H2BN4GO - Molecular functioniProtein-protein interaction databasesBioGridi 1 interactor.IntActi 2 interactors.STRINGi Structurei3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiFamily & DomainsiRegionFeature keyPosition(s)DescriptionActionsGraphical viewLengthRegioniDocking domain 29DomainiThe docking domain is responsible for the weaker heterodimerization with H2B.Manual assertion based on experiment ini"Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA.", , , , , , , ,
[] [] []Cited for: FUNCTION, DOMAIN.Sequence similaritiesiBelongs to the .Phylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Family and domain databasesInterProi Histone-fold.
Histone_H2A. PRINTSi HISTONEH2A. SMARTi H2A. 1 hit. SUPFAMi SSF47113. 1 hit. SequenceiSequence statusi: Complete.P0C5Z0-1 []
50MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR
100TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST
110 LFNTTTISQV APGED
11512,713December 4, 2007 - v1Checksum:iF7CA51BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .CCDSi
Genome annotation databasesEnsembli; ; . ; ; . GeneIDi
UCSCi human. Similar proteinsi mRNA. Translation: . Genomic DNA. No translation available. Genomic DNA. No translation available. Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .CCDSi
3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiProtein-protein interaction databasesBioGridi 1 interactor.IntActi 2 interactors.STRINGi PTM databasesiPTMneti PhosphoSitePlusi Polymorphism and mutation databasesDMDMi Proteomic databasesPaxDbi PeptideAtlasi PRIDEi Protocols and materials databasesDNASUi Structural Biology KnowledgebaseGenome annotation databasesEnsembli; ; . ; ; . GeneIDi
UCSCi human. Organism-specific databasesCTDi
GeneCardsi
HGNCi H2AFB2.
H2AFB3. MIMi gene. neXtProti PharmGKBi GenAtlasiPhylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Miscellaneous databasesGeneWikii
PROi SOURCEiGene expression databasesBgeei CleanExi
Genevisiblei HS. Family and domain databasesInterProi Histone-fold.
Histone_H2A. PRINTSi HISTONEH2A. SMARTi H2A. 1 hit. SUPFAMi SSF47113. 1 hit. ProtoNeti Q96PR7Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007Last sequence update: December 4, 2007Last modified: February 28, 2018This is version 82 of the entry and version 1 of the sequence. Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi,